| Identification | More | [Name]
Triethylenetetramine | [CAS]
112-24-3 | [Synonyms]
1,4,7,10-TETRAAZADECANE
1,8-diamino-3,6-diazaoctane
3,6-DIAZAOCTANE-1,8-DIAMINE
LABOTEST-BB LTBB000434
n,n'-bis(2-aminoethyl)-1,2-ethanediamine
N,N'-BIS(2-AMINOETHYL)ETHYLENEDIAMINE
N,N'-DI(2-AMINOETHYL)ETHYLENEDIAMINE
TRIEN
Trientine
TRIETHYLENETETRAMINE
1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-
1,2-Ethanediamine,N,N’-bis(2-aminoethyl)-
2-Ethanediamine,N,N’-bis(2-aminoethyl)-1
3,6-Diazaoctanethylenediamin
Araldite Hardener HY 951
Araldite HY 951
aralditehardenerhy951
aralditehy951
DEH 24
deh24 | [EINECS(EC#)]
203-950-6 | [Molecular Formula]
C6H18N4 | [MDL Number]
MFCD00008169 | [Molecular Weight]
146.23 | [MOL File]
112-24-3.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless to light yellow or amber viscous liquid | [Melting point ]
12 °C(lit.)
| [Boiling point ]
266-267 °C(lit.)
| [density ]
0.982 g/mL at 25 °C(lit.)
| [vapor density ]
~5 (vs air)
| [vapor pressure ]
<0.01 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.496(lit.)
| [Fp ]
290 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
alcohol: soluble | [form ]
Slightly viscous yellow
liquid; commercially available form is 95–98%
pure, and impurities include linear, branched,
and cyclic isomers. | [pka]
pK1:3.32(+4);pK2:6.67(+3);pK3:9.20(+2);pK4:9.92(+1) (20°C) | [color ]
Yellowish liquid or oil | [PH]
10-11 (10g/l, H2O, 20℃) | [Stability:]
Syable. Incompatible with strong oxidizing agents, strong acids. | [explosive limit]
0.7-7.2%(V) | [Water Solubility ]
SOLUBLE | [FreezingPoint ]
12℃ | [Sensitive ]
Moisture Sensitive | [Merck ]
14,9663 | [BRN ]
605448 | [Exposure limits]
ACGIH: TWA 1 ppm (Skin)
NIOSH: TWA 1 ppm(4 mg/m3) | [InChI]
1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2 | [Contact allergens]
Triethylenetetramine is used as an amine hardener in
epoxy resins of the bisphenol A type. Cross-sensitivity is
possible with diethylenetriamine and diethylenediamine. | [InChIKey]
VILCJCGEZXAXTO-UHFFFAOYSA-N | [SMILES]
NCCNCCNCCN | [LogP]
-2.65 at 20℃ | [CAS DataBase Reference]
112-24-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Triethylenetetramine(112-24-3) | [EPA Substance Registry System]
112-24-3(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
colourless to light yellow or amber viscous liquid | [Uses]
Triethylenetetramine is a selective CuII-chelator; crosslinking agent. Triethylenetetramine is undergoing trials for the treatment of heart failure in patients with diabetes. | [General Description]
A yellowish liquid. Less dense than water. Combustible, though may be difficult to ignite. Corrosive to metals and tissue. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used in detergents and in the synthesis of dyes, pharmaceuticals and other chemicals. | [Reactivity Profile]
TRIETHYLENETETRAMINE(112-24-3) is a strong base; reacts violently with strong oxidants; attacks aluminum, zinc, copper and its alloys. Handling Chemicals Safely 198. p. 934). | [Air & Water Reactions]
Soluble in water. | [Health Hazard]
Vapors from hot liquid can irritate eyes and upper respiratory system. Liquid burns eyes and skin. May cause sensitization of skin. | [Fire Hazard]
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. | [Description]
Cross sensitivity is
possible with diethylenetriamine and diethylenediamine. | [Definition]
ChEBI: 2,2,2-tetramine is a polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens. It has a role as a copper chelator. It is a tetramine and a polyazaalkane. | [Production Methods]
TETA is manufactured by reacting ethylene dichloride and
ammonia under controlled conditions. | [Brand name]
Syprine (Merck). | [Flammability and Explosibility]
Nonflammable | [Toxicology]
Triethylenetetramine may induce lung edema on inhalation of its vapors. The compound is also an effective skin sensitizer. Following repeated dosing (ca. 50 mg each, 17 – 55 times) onto the skin of pregnant and nonpregnant guinea pigs, significant amounts were absorbed by the strongly irritated skin, leading to toxic effects in the kidneys, liver, brain, and placenta and causing abortion. Triethylenetetramine proved to be a mutagen in vitro but not in vivo.
| [Carcinogenicity]
TETA was mutagenic in bacterial assays
and was positive in sister chromatid exchanges
and unscheduled DNA synthesis tests in vitro.8
It was not clastogenic in the mouse micronucleus
test in vivo after oral or intraperitoneal
administration. | [Purification Methods]
Dry the amine with sodium, then distil it under a vacuum. Further purification has been via the nitrate or the chloride salts. For example, Jonassen and Strickland [J Am Chem Soc 80 312 1958] separated TRIEN from admixture with TREN (38%) by solution in EtOH, cooling to approximately 5o in an ice-bath and adding conc HCl dropwise from a burette, keeping the temperature below 10o, until all of the white crystalline precipitate of TREN.HCl (see p 191) had formed and was removed. Further addition of HCl then precipitated thick, creamy white TRIEN.HCl (see below) which was crystallised several times from hot water by adding an excess of cold EtOH. The crystals were finally washed with Me2CO, then Et2O and dried in a vacuum desiccator. [Beilstein 4 H 255, 4 II 695, 4 III 542, 4 IV 1242.] | [Toxics Screening Level]
The initial threshold screening level (ITSL) for triethylene tetramine (TETA) is 8 μg/m 3 based on annual averaging time. |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H312-H314-H317-H412 | [Precautionary statements ]
P261-P272-P273-P280-P303+P361+P353-P305+P351+P338 | [Hazard Codes ]
C | [Risk Statements ]
R21:Harmful in contact with skin.
R34:Causes burns.
R43:May cause sensitization by skin contact.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2259 8/PG 2
| [WGK Germany ]
2
| [RTECS ]
YE6650000
| [Autoignition Temperature]
335 °C | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29212900 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Acute Tox. 4 Dermal
Aquatic Chronic 2
Eye Dam. 1
Skin Corr. 1B
Skin Sens. 1 | [Safety Profile]
Poison by intravenous
route. Moderately toxic by ingestion and
skin contact. An experimental teratogen.
Experimental reproductive effects. Mutation
data reported. A corrosive irritant to skin,
eyes, and mucous membranes. Causes skin
sensitization. Combustible when exposed to
heat or flame. Ignites on contact with
cellulose nitrate of high surface area. Can
react with oxidizing materials. To fight fire,
use CO2, dry chemical, alcohol foam. When
heated to decomposition it emits toxic
fumes of NOx. | [Hazardous Substances Data]
112-24-3(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: 2.5 g/kg (Spitz) |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ammonium hydroxide-->Ethylenediamine-->1,2-Dichloroethane-->Dichloroethane-->Diethylenetriamine-->Polyethylene-polyamines-->Tetraethylenepentamine | [Preparation Products]
Diethylenetriamine-->Triethylenediamine-->1,1,4,7,10,10-Hexamethyltriethylenetetramine-->triethylene tetraamine hexamethylene phosphoric acid-->Triethylenetetramine tetrahydrochloride-->Triethylenetetramine Dihydrochloride-->Piperazine-1,4-diethylamine-->1-(2-Hydroxyethyl)-2-imidazolidinone-->1-(2-Aminoethyl)imidazolidin-2-one-->3H,6H-2a,5,6,8a-Tetraazaacenaphthylene, octahydro-5a,8b-dimethyl-, cis- |
|
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|